This Gene-Editing Tech Might Be Too Dangerous To Unleash | WIRED
That danger may be more real than scientists first thought. Four years ago, when Harvard biologist Kevin Esvelt first suggested the idea of building gene drives with the newly discovered Crispr gene editing system, he was thinking about extinction. Specifically, preventing endangered wildlife from disappearing by spreading a fertility-reducing gene through the invasive animals competing with them for resources. Conservation biologists took the idea and ran with it; they're now considering gene drives to save native birds in Hawaii, New Zealand, and the Farallones. But now, Esvelt is saying they should slow down.
Thu Nov 16 16:16:13 2017
That's based on the results of a new mathematical model he and his colleagues published on Thursday on the bioRxiv preprint server. Taking into account things like how often Crispr screws up and the likelihood of protective mutations arising, their work shows how gene drives could be ruthlessly aggressive. Just a few engineered organisms could irrevocably alter an ecosystem. While Esvelt doesn't view the technology as inherently threatening, he is now preaching that it deserves a bold new caution in how it's applied.